5 Essential Elements For Demerol 1500 mg/30 ml interactions
5 Essential Elements For Demerol 1500 mg/30 ml interactions
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Animal details official reproductive and developmental toxicology scientific studies for meperidine haven't been finished.
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If concomitant use cimetidine and DEMEROL Injection is important, watch sufferers for respiratory depression and sedation at Regular intervals.
If the extent of soreness will increase just after dosage stabilization, make an effort to identify the supply of greater agony right before raising the DEMEROL Injection dosage. If immediately after escalating the dosage, unacceptable opioid-similar adverse reactions are observed (such as an increase in pain after a dosage boost), consider lessening the dosage [see Warnings and safeguards (five)].
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If opioid use is necessary for an prolonged time frame inside of a pregnant girl, advise the patient of the potential risk of Neonatal Opioid Withdrawal Syndrome, which may be lifetime-threatening if not recognized and handled. make sure that management by neonatology authorities is going to be readily available at supply. (five.four)
Mutagenesis Studies in animals To guage the mutagenic prospective of meperidine have not been carried out.
Misuse and abuse of DEMEROL Injection will increase chance of overdose, which can cause central anxious procedure and respiratory despair, hypotension, seizures, and Loss of life. The risk is enhanced with concurrent abuse of DEMEROL Injection with Liquor and/or other CNS depressants.
Phenytoin: The hepatic metabolism of meperidine could possibly be Increased by phenytoin. Concomitant administration resulted in decreased half-everyday living and bioavailability with improved clearance of meperidine in healthful topics; nevertheless, blood concentrations of normeperidine ended up enhanced [see Drug Interactions (7)].
This medication will trigger constipation. If you don't Possess a bowel movement for 3 days, connect with your care workforce.
The causal job of opioids while in the medical syndrome of hypogonadism is unfamiliar since the several healthcare, physical, Life style, and psychological stressors which could read more affect gonadal hormone amounts haven't been adequately managed for in studies executed so far [see Adverse Reactions (six)].
people with Chronic Pulmonary illness: DEMEROL Injection handled individuals with significant chronic obstructive pulmonary sickness or cor pulmonale, and people using a significantly lessened respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression are at increased danger of reduced respiratory travel which include apnea, even at proposed dosages of DEMEROL Injection [see Warnings and safeguards (5.2)].
Meperidine is known for being substantially excreted because of the kidney, and the potential risk of adverse reactions to this drug might be greater in clients with impaired renal function.
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